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Applied surrogate endpoint evaluation methods with SAS and R

By: Alonso, Ariel.
Contributor(s): Bigirumurame, Theophile [Co-author] | Burzykowski, Tomasz [Co-author] | Buyse, Marc [Co-author] | Molenberghs, Geert [Co-author] | Muchene, Leacky [Co-author] | Perualila, Nolen Joy [Co-author] | Shkedy, Ziv [Co-author] | Elst, Wim Van der [Co-author].
Material type: materialTypeLabelBookSeries: Chapman & hall/crc biostatistics series. Publisher: Boca Raton CRC Press 2017Description: xvii, 373 p. Includes bibliographical references and index.ISBN: 9781482249361.Subject(s): Medicine - Research methodology | R (Computer program language) | SAS (Computer file) | Clinical trials - Statistical methodsDDC classification: 610.72 Summary: An important factor that affects the duration, complexity and cost of a clinical trial is the endpoint used to study the treatment’s efficacy. When a true endpoint is difficult to use because of such factors as long follow-up times or prohibitive cost, it is sometimes possible to use a surrogate endpoint that can be measured in a more convenient or cost-effective way. This book focuses on the use of surrogate endpoint evaluation methods in practice, using SAS and R. https://www.crcpress.com/Applied-Surrogate-Endpoint-Evaluation-Methods-with-SAS-and-R/Alonso-Bigirumurame-Burzykowski-Buyse-Molenberghs-Muchene-Perualila-Shkedy-Elst/p/book/9781482249361
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Slot 1716 (2 Floor, East Wing) Non-fiction 610.72 A5A7 (Browse shelf) Available 201392

Table of Contents

Introductory Material. Introduction. Notation and Example Datasets. The History of Surrogate Endpoint Validation. Contemporary Surrogate Endpoint Evaluation Methods. Multiple-Trial Surrogate Endpoint Evaluation Methods. Two Continuous Outcomes. Two Survival Endpoints. Two Categorical Endpoints. A Categorical and a Continuous Endpoint. A Survival and a Continuous Endpoint. A Survival and a Categorical Endpoint. Two Longitudinal Endpoints. A Longitudinal and a Survival Endpoint. Additional Considerations and Further Topics. Software Details. An Alternative Surrogate Endpoint Evaluation Framework: Causal-Inference. Surrogate Endpoint Evaluation Methods in Small Samples. Construction and Evaluation of Genetic Biomarkers in Early Drug Development Experiments. Additional Considerations.

An important factor that affects the duration, complexity and cost of a clinical trial is the endpoint used to study the treatment’s efficacy. When a true endpoint is difficult to use because of such factors as long follow-up times or prohibitive cost, it is sometimes possible to use a surrogate endpoint that can be measured in a more convenient or cost-effective way. This book focuses on the use of surrogate endpoint evaluation methods in practice, using SAS and R.

https://www.crcpress.com/Applied-Surrogate-Endpoint-Evaluation-Methods-with-SAS-and-R/Alonso-Bigirumurame-Burzykowski-Buyse-Molenberghs-Muchene-Perualila-Shkedy-Elst/p/book/9781482249361

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